Stem Cell Therapy for CNS diseases -Therapeutic Role, Current Status, Challenges and Perspectives

Maiti, S. K.1 and Ninu, A. R. 1*

1Division of Surgery, IVRI, Izatnagar, U. P -243122

*Corresponding author: Ninu A. R., PhD Scholar, Division of Surgery, Indian Veterinary Research Institute, Izatnagar, Bareilly, (U. P.)-243122, India. Email: ar.ninu@gmail.com

Abstract :

Many of the human central nervous system (CNS) diseases are mimicked in animal models to evaluate the efficacy of stem cell therapy. The therapeutic role of stem cell in replacement of diseased neurons, oligodendrocytes, astrocytes, secretion of neurotrophic factors and delivery of therapeutics/genes has been reported. Scaffolds can be used for sustained delivery of stem cells and may play role in promoting their neuronal differentiation. Though many of the animal studies have progressed to clinical trials, stem cell therapy in clinical setting is still facing so many challenges. This review discusses the therapeutic role of stem cells, use of scaffolds in stem cell therapy, clinical status, challenges and future perspectives of stem cell therapy in central nervous system diseases. Keywords: stem cell therapy, CNS diseases, cell replacement, gene therapy, challenges, scaffold.